Mental Health research centre
Identification of persons in the latent stage of Parkinson's disease: the first results of the Russian observational study PARKINLAR
Nowadays it is firmly established that Parkinson's disease (PD) is characterized by a long, many years of latent stage, during which the increasing death of neurons is not yet accompanied by the appearance of distinct motor symptoms. For a long time, the neurodegenerative process is manifested by a combination of premotor symptoms - sensory (loss of smell, violation of color vision, pain syndrome), vegetative (constipation, erectile dysfunction, sympathetic denervation of the myocardium, etc.), neuropsychological (conduct disorder in the phase of sleep with rapid eye movements, depression, etc.). These symptoms can occur for 15-25 years before the manifestation of the typical movement disorders, and conversion in the premotor phase motor marks the death is not less than 60% of nigral neutrons. It is obvious that the possibility of neuroprotection is maximized in the latent stage of PD. For effective use of the existing long-term "therapeutic window" is required to develop reliable biomarkers lifetime latent stage PD - neuroimaging, neurophysiology, molecular pathochemical.